Exploring the epigenetic drug discovery landscape


Molecular imprinting has become an attractive synthetic approach for the fabrication of novel functional polymers with pre-designed molecular target selectivity. Such molecularly imprinted polymers (MIPs) have been applied in wide range of areas such as chemical and biological sensors, solid phase extraction and drug assays owing to their inherent robustness, reusability and reproducibility. Furthermore, MIPs can also be used as tools for studies concerning antibody/receptor binding site mimicry as well as being used as antibody substitutes for biomedical applications. Viral detection is a rapidly growing field owing to its increasing prevalence and ongoing evolution of viral variants and drug resistance. Therefore, this calls for effective detection, surveillance and control. Herein, we highlight and summarize the literature on the utilization of MIPs for human virus detection. Particularly, MIPs afford great potential for rapid virus detection as well as other recognition-based viral studies.

Expert Opinion in Drug Discovery
Prachayasittikul V, Prathipati P, Pratiwi R, Phanus-umporn C, Malik AA, Schaduangrat N, Seenprachawong K, Wongchitrat P, Supokawej A, Prachayasittikul V, Wikberg JES, Nantasenamat C. Exploring the epigenetic drug discovery landscape. Expert Opinion in Drug Discovery 12 (2017) 345-362.